Hypercellular Encapsulated Neuroma Imitating Desmoplastic Melanoma. (May 2019)

• Record Type: Journal Article
• Authors: May, Caitlin; LeBoit, Philip; McCalmont, Timothy; Argenyi, Zsolt
• Is Part Of: American journal of dermatopathology. Volume 41:Number 5(2019)
• Publication Date: 2019-05
• Subjects: neuroma -- desmoplastic melanoma -- nerve sheath; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000001302
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Abstract: Palisaded encapsulated neuromas (PENs) are benign cutaneous nerve sheath proliferations that typically occur as flesh-colored papules solitarily on the head and neck in adults, with a slight predilection for females. Histopathologically, they are partially or completely encapsulated intradermal nodules with Schwann cells and axons in fascicles separated by clefts. Although these features are often characteristic, the hypercellular variant of PEN can pose a diagnostic challenge in distinguishing between other cellular neural and melanocytic lesions. We herein report a case of hypercellular PEN, which showed striking similarity to desmoplastic melanoma.