Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman. Issue 2 (11th April 2016)

• Record Type: Journal Article
• Authors: Steussy, Bryan; Lekostaj, Jacqueline; Qian, Qining; Rosenthal, Nancy; Holman, Carol J.; Syrbu, Sergei; Darbro, Benjamin; Bossler, Aaron; Karandikar, Nitin J.
• Is Part Of: Laboratory medicine. Volume 47:Issue 2(2016)
• Page Start: 155
• Page End: 157
• Publication Date: 2016-04-11
• Subjects: transdifferentiation -- lymphoma -- leukemia -- histiocytic -- sarcoma -- B cell; Clinical chemistry -- Periodicals; Pathology -- Periodicals; Medical technology -- Periodicals; Chemistry, Clinical; Pathology; Medical Laboratory Science; Clinical chemistry; Medical technology; Pathology; Electronic journals; Periodicals; Periodicals; 616
• DOI: 10.1093/labmed/lmw011
• Languages: English
• ISSNs: 0007-5027

Abstract

Abstract : We report an instructive case of acute myeloid leukemia with histiocytic differentiation ( acute histiocytic leukemia ) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M 5 c)–like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.