Total synthesis and anticancer activity of the natural oleanolic acid bidesmoside saponin, albidoside A, isolated from the roots of Acacia albida. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Guo, Tiantian; Song, Yiming; Lu, Yinghui; Li, Guolin; Liu, Tian; Han, Wenrong; Song, Weiguo; Yang, Chuncheng; Li, Fahui; Liu, Qingchao
• Is Part Of: Journal of chemical research. Volume 44:Issue 1/2(2020)
• Page Start: 42
• Page End: 49
• Publication Date: 2020-01
• Subjects: albidoside A -- oleanolic acid bidesmoside saponin -- glycosylation -- antitumor activity; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/1747519819884152
• Languages: English
• ISSNs: 1747-5198

Abstract

The first synthesis of a natural triterpenoid saponin bearing N -acetylglucosamine, albidoside A, which is isolated from the roots of Acacia albida, is concisely achieved in a convergent strategy. Preliminary pharmacological research shows anticancer activity against HL-60, MCF-7, MDA-MB-231, Hep-2, and Hela cell lines. In particular, it exhibited good selectivity, which is five times more cytotoxic toward Hep-2 cells (IC50 = 8.91 μM) than the Hela cell line.