TRPing the homeostatic alarm — Melanoma cells are selectively vulnerable to TRPML1 deletion. (December 2019)

• Record Type: Journal Article
• Authors: Jung, Jewon; Venkatachalam, Kartik
• Is Part Of: Cell calcium. Volume 84(2019)
• Publication Date: 2019-12
• Subjects: Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2019.102082
• Languages: English
• ISSNs: 0143-4160

Abstract

Highlights: Recent study by Kasitinon et al. describe a role for TRPML1 in melanoma. Deletion of the channel results in toxic ERK and mTORC1 hyperactivation in melanoma. Perspective on TRPML1 function in cancer is provided. Abstract: To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1.