Irreversible Electroporation in Hepatopancreaticobiliary Tumours. Issue 1 (February 2018)

• Record Type: Journal Article
• Authors: Ruarus, A.H.; Vroomen, L.G.P.H.; Puijk, R.S.; Scheffer, H.J.; Zonderhuis, B.M.; Kazemier, G.; van den Tol, M.P.; Berger, F.H.; Meijerink, M.R.
• Is Part Of: Canadian Association of Radiologists journal. Volume 69:Issue 1(2018)
• Page Start: 38
• Page End: 50
• Publication Date: 2018-02
• Subjects: Irreversible electroporation -- IRE -- Pancreatic neoplasms -- Liver neoplasms -- Perihilar cholangiocarcinoma; Radiology, Medical -- Periodicals; Radiology, Medical -- Canada -- Periodicals; 616.0757
• DOI: 10.1016/j.carj.2017.10.005
• Languages: English
• ISSNs: 0846-5371

Abstract

Hepatopancreaticobiliary tumours are often diagnosed at an advanced disease stage, in which encasement or invasion of local biliary or vascular structures has already occurred. Irreversible electroporation (IRE) is an image-guided tumour ablation technique that induces cell death by exposing the tumour to high-voltage electrical pulses. The cellular membrane is disrupted, while sparing the extracellular matrix of critical tubular structures. The preservation of tissue integrity makes IRE an attractive treatment option for tumours in the vicinity of vital structures such as splanchnic blood vessels and major bile ducts. This article reviews current data and discusses future trends of IRE for hepatopancreaticobiliary tumours.