Angiopoietin: A Novel Neuroprotective/Neurotrophic Agent. (15th July 2019)

• Record Type: Journal Article
• Authors: Yin, Jian; Gong, Ge; Liu, Xinhui
• Is Part Of: Neuroscience. Volume 411(2019)
• Page Start: 177
• Page End: 184
• Publication Date: 2019-07-15
• Subjects: AAV adenovirus associated virus -- Ade adenovirus encoding -- ad-Ang1 adenovirus mediated Ang1 -- Ang angiopoietin -- BBB blood–brain barrier -- BSCB blood-spinal cord barrier -- COMP cartilage oligomeric matrix protein -- CNS central nervous system -- dbcAMP dibutyryl cyclic AMP -- DRG dorsal root ganglion -- ECs endothelial cells -- FAK focal adhesion kinase -- GABA aminobutyric acid -- MMP-9 matrix metalloproteinase-9 -- miRs MicroRNAs -- NF neurofilament -- NGF nerve growth factor -- NMO neuromyelitisoptica -- NPCs neural progenitor cells -- PI3K/Akt phosphatidylinositol 3-kinase/protein kinase B -- SCI spinal cord injury -- SD-induced serum deprivation-induced -- Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -- Tie2 tyrosine kinase with immunoglobulin-like and EGF-like domains 2 -- Tyr tyrosinase -- trkA tyrosinekinase -- VE-cadherin vascular endothelial-cadherin -- VEGF vascular endothelial growth factor -- ZO-1 zonula occluden-1 -- ZO-2 zonula occluden-2; angiopoietin -- neuroprotection -- neurotrophin -- Tie2 -- β1-integrin; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2019.05.038
• Languages: English
• ISSNs: 0306-4522

Abstract

Abstract: Angiopoietin (Ang) is an angiogenic factor, but its neuroprotective and neurotrophic effects have recently come to light. Ang exerts neuroprotective effects by inhibiting neuronal apoptosis, protecting the blood–brain/blood-spinal cord barrier, reducing inflammation and promoting neovascularization. In addition, Ang can also promote neural development and neurite outgrowth via activation of the PI3K/Akt signaling pathway and binding to the Tie2 receptor and/or integrin receptor. In addition, Ang and vascular endothelial growth factor (VEGF) are known to interact in blood vessels in the nervous system and the combination of Ang and VEGF can mitigate the negative effects of VEGF, such as inflammation and local edema. These data indicated that Ang is a novel neuroprotective/neurotrophic factor, which may become a new tool for the treatment of nerve injury. Highlights: Angiopoietin inhibits neuronal apoptosis and promotes neurite outgrowth. Ang promotes angiogenesis, protects the blood–brain/blood spinal cord barrier and reduces inflammation Ang plays a neuroprotective or neurotrophic role by combining to Tie-2 or/and integrin receptors.