Bioactive 3, 8‐Epoxy Iridoids from Valeriana jatamansi. Issue 5 (8th April 2019)

• Record Type: Journal Article
• Authors: Quan, Li‐Qiu; Su, Li‐Hua; Qi, Shi‐Gang; Xue, Yong; Yang, Tao; Liu, Dan; Zhao, Xu‐Dong; Li, Rong‐Tao; Li, Hong‐Mei
• Is Part Of: Chemistry & biodiversity. Volume 16:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-08
• Subjects: Valeriana jatamansi -- 3, 8-epoxy iridoids -- cytotoxicity -- inhibition of NO production -- phytochemistry; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201800474
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Twelve 3, 8‐epoxy iridoids, including four new compounds, jatamanins R–U (1 –4 ), and eight known compounds (5 –12 ), were obtained from the roots and rhizomes of Valeriana jatamansi . The structures were elucidated from analysis of spectroscopic data. The absolute configurations of 1 –4 were determined by comparison of experimental and literature ECD spectra. Moreover, the compounds were evaluated for cytotoxic effects against glioma stem cells, inhibition of NO production, activity against influenza A virus and reversal of multidrug resistance of HepG2/ADR cells. Compounds 9 and 12 showed significant cytotoxic potency against GSC‐18# (IC50 =1.351 and 4.439 μg ml −1, respectively) and GSC‐3# (IC50 =10.88 and 6.348 μg ml −1, respectively) glioma stem cells, while compound 12 was also slightly less potent against GSC‐12# (IC50 =13.45 μg ml −1 ) glioma stem cell growth. In addition, compounds 9 and 12 displayed obvious inhibition of NO production (IC50 =4.6 and 15.8 μm, respectively). Abstract :