Telescoped, Divergent, Chemoselective C1 and C1‐C1 Homologation of Imine Surrogates: Access to Quaternary Chloro‐ and Halomethyl‐Trifluoromethyl Aziridines. Issue 8 (24th January 2019)

• Record Type: Journal Article
• Authors: Ielo, Laura; Touqeer, Saad; Roller, Alexander; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 8(2019)
• Page Start: 2479
• Page End: 2484
• Publication Date: 2019-01-24
• Subjects: aziridines -- carbenoids -- chemoselectivity -- homologation -- lithium; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201812525
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A conceptually novel, high‐yielding, mono‐ or bis‐homologation was realized with lithium halocarbenoids and enables the one‐step, fully chemocontrolled assembly of a new class of quaternary trifluoromethyl aziridines. Trifluoroacetimidoyl chlorides (TFAICs) act as convenient electrophilic platforms, enabling the addition of either one or two homologating elements by simply controlling the stoichiometry of the process. Mechanistic studies highlighted that the homologation event, carried out with two different carbenoids (LiCH2 Cl and LiCH2 F), leads to fluoromethyl analogues in which the first nucleophile is employed for constructing the cycle and the second for decorating the resulting molecular architecture. Abstract : Mono‐ or bis‐homologation was realized with lithium halocarbenoids for the assembly of trifluoromethyl aziridines. Trifluoroacetimidoyl chlorides act as electrophilic platforms, enabling the addition of either one or two homologating elements. Use of two different carbenoids leads to fluoromethyl analogues in which the first nucleophile is employed for constructing the cycle and the second one for decorating the resulting molecular architecture.