Metal‐Helix Frameworks from Short Hybrid Peptide Foldamers. Issue 8 (25th January 2019)

• Record Type: Journal Article
• Authors: Misra, Rajkumar; Saseendran, Abhijith; Dey, Sanjit; Gopi, Hosahudya N.
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 8(2019)
• Page Start: 2251
• Page End: 2255
• Publication Date: 2019-01-25
• Subjects: foldamers -- frameworks -- helices -- metal coordination -- X-ray diffraction; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201810849
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The potential of structured peptides has not been explored much in the design of metal‐organic frameworks (MOFs). This is partly due to the difficulties in obtaining stable secondary structures from the short α‐peptide sequences. Here we report the design, crystal conformations, coordination site dependent different silver coordinated frameworks of short α, γ‐hybrid peptide 12‐helices consisting of terminal pyridyl moieties and the utility of metal‐helix frameworks in the adsorption of CO2 . Upon silver ion coordination the 12‐helix terminated by the 3‐pyridyl derivatives adopted a 2:2 macrocyclic structure, while the 12‐helix terminated by the 4‐pyridyl derivatives displayed remarkable porous metal‐helix frameworks. Both head‐to‐tail intermolecular H‐bonds of the 12‐helix and metal ion coordination have played an important role in stabilizing the ordered metal‐helix frameworks. The studies described here open the door to design a new class of metal‐organic‐frameworks from peptide foldamers. Abstract : Helical polymerization : The porous metal‐helix frameworks from the short α, γ‐hybrid peptide foldamers terminated by the metal coordinating bis(pyridyl) ligands and silver ions are reported. These results suggest that helical foldamers can be used as templates to design new metal‐helix frameworks.