Mimengosides J and K: two new neuroprotective triterpenoids from the fruits of Buddleja lindleyana. Issue 5 (4th May 2019)

• Record Type: Journal Article
• Authors: Zhang, Wei; Li, Zheng; Xu, Feng-Qing; Ren, Ya-Shuo; Xu, Shuang-Wang; Wang, Tong-Sheng; Liu, Jin-Song; Wu, De-Ling
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 5(2019)
• Page Start: 426
• Page End: 434
• Publication Date: 2019-05-04
• Subjects: Buddleja lindleyana -- mimengosides J and K -- triterpenoids -- MPP+induced neurotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1516211
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1 ) and K (2 ), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana . Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP + ) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease.