Hyperascyrins L − N, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron. Issue 5 (4th May 2019)

• Record Type: Journal Article
• Authors: Zhen, Bo; Hu, Jia-Wen; Wang, Jia-Jia; Shi, Meng-Jiao; Li, Li; Ci, Ren; Jiang, Jian-Dong; Ji, Teng-Fei
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 5(2019)
• Page Start: 409
• Page End: 418
• Publication Date: 2019-05-04
• Subjects: Guttiferae -- Hypericum ascyron -- methylated polycyclic polyprenylated acylphloroglucinols (mPPAPs) -- neuroprotection -- hepatoprotective; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1581175
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Seven natural compounds, including new compounds hyperascyrins L-N (1 -3 ) and four known compounds (4-7 ), were acquired from the aerial parts of Hypericum ascyron, that were all identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives (mPPAPs). The structures of these compounds were established by NMR spectroscopy, experimental and calculated electronic circular dichroism (ECD) data. The neuroprotective activities and hepatoprotective activity of these compounds (10 µ M) were evaluated. Compounds 1, 2 and 3 exhibited neuroprotection activity. Compounds 1 and 3 show hepatoprotective activity. Graphical Abstract: