Discontinuous transcription. (31st December 2018)

• Record Type: Journal Article
• Authors: Smirnov, Evgeny; Hornáček, Matúš; Vacík, Tomáš; Cmarko, Dušan; Raška, Ivan
• Is Part Of: Nucleus. Volume 9:Number 1(2018)
• Page Start: 149
• Page End: 160
• Publication Date: 2018-12-31
• Subjects: Pulsing transcription -- bursting -- transcriptional fluctuation -- discontinuous gene expression -- kinetics; Cell nuclei -- Periodicals; Biology -- Periodicals; Biology; Cell nuclei; Periodicals; 571.6605
• DOI: 10.1080/19491034.2017.1419112
• Languages: English
• ISSNs: 1949-1034

Abstract

ABSTRACT: Numerous studies based on new single-cell and single-gene techniques show that individual genes can be transcribed in short bursts or pulses accompanied by changes in pulsing frequencies. Since so many examples of such discontinuous or fluctuating transcription have been found from prokaryotes to mammals, it now seems to be a common mode of gene expression. In this review we discuss the occurrence of the transcriptional fluctuations, the techniques used for their detection, their putative causes, kinetic characteristics, and probable physiological significance.