CMA restricted to mammals and birds: myth or reality?. Issue 7 (3rd July 2018)

• Record Type: Journal Article
• Authors: Lescat, Laury; Herpin, Amaury; Mourot, Brigitte; Véron, Vincent; Guiguen, Yann; Bobe, Julien; Seiliez, Iban
• Is Part Of: Autophagy. Volume 14:Issue 7(2018)
• Page Start: 1267
• Page End: 1270
• Publication Date: 2018-07-03
• Subjects: Chaperone-mediated autophagy -- evolution -- fish -- LAMP2A -- RNA-seq; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2018.1460021
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis essential for the control of intermediary metabolism. So far, the absence of any identifiable LAMP2A – a necessary and limiting protein for CMA – outside of the tetrapod clade, led to the paradigm that this cellular function was (presumably) restricted to mammals and birds. However, after we identified expressed sequences displaying high sequence homology with the mammalian LAMP2A in several fish species, our findings challenge that view and suggest that CMA likely appeared much earlier during evolution than initially thought. Hence, our results do not only shed an entirely new light on the evolution of CMA, but also bring new perspectives on the possible use of complementary genetic models, such as zebrafish or medaka for studying CMA function from a comparative angle/view.