Apolipoproteins A1, B, and other prognostic biochemical cardiovascular risk factors in patients with beta-thalassemia major. Issue 2 (7th February 2016)

• Record Type: Journal Article
• Authors: Ghorban, Khodayar; Shanaki, Mehrnoosh; Mobarra, Naser; Azad, Mehdi; Asadi, Jahanbakhsh; Pakzad, Reza; Ehteram, Hassan
• Is Part Of: Hematology. Volume 21:Issue 2(2016)
• Page Start: 113
• Page End: 120
• Publication Date: 2016-02-07
• Subjects: Apolipoprotein -- Beta-thalassemia major -- Cardiovascular disease -- Oxidative stress; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1179/1607845415Y.0000000016
• Languages: English
• ISSNs: 1024-5332

Abstract

Abstract : Objectives : The occurrence of cardiac iron deposition is one of the late effect of iron over load which causes cardiovascular disease (CVD) in patients who are affected by beta-thalassemia major. Evaluation of some cardiovascular risk factors plays a crucial role in prediction and prevention of CVD. Subjects and methods : This study consisted of 70 young adult subjects with beta-thalassemia major (beta-TM) (aged <30 years) and 71 age- and sex-matched healthy subjects as control group in the range of 20–30 years. Hematological and biochemical laboratory parameters including apolipoprotein (Apo)A1 and ApoB, oxidative stress biomarker pro-oxidant–antioxidant balance (PAB), homocysteine, serum high-sensitivity C-reactive protein (hs-CRP), and lipid profile were evaluated. Results : ApoA1, ApoB, lipid profiles, and homocysteine were significantly decreased in patients group ( P < 0.001); however, very low-density lipoprotein and also mean corpuscular hemoglobin concentration ( P > 0.05) were different. Some elements included ferritin ( P < 0.001), PAB ( P < 0.001), and ApoB/apoA1 ratio ( P < 0.05) statistically increased in patients, whereas hs-CRP ( P > 0.05) was not significantly different in study groups. Exception of high-density lipoprotein ( P > 0.05), other lipid profiles, and apoB had a negative meaningful correlation with PAB ( P < 0.05). Likewise, apoA1, apoB, apoB/A1 ratio with apoB and homocysteine showed a strong correlation ( P < 0.05). We did not find a slight correlation between apoB/A1 ratio in the company of oxidative stress marker PAB ( r = −0.366; P = 0.086). We found a statistical correlation between apoB/A1 and homocysteine ( P < 0.05). Discussion : Higher level of some risk factors like PAB values, apoB/A1 ratio concentration, and lipid profiles is able to involve in the prognostic pathological consequences in patients with beta-thalassemia major. Even so, they contribute toward the gradual development of CVD.