Association between new onset diabetic retinopathy and monocyte chemoattractant protein-1 (MCP-1) polymorphism in Japanese type 2 diabetes. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Ninomiya, Hiroyo; Katakami, Naoto; Osonoi, Takeshi; Saitou, Miyoko; Yamamoto, Yuichi; Takahara, Mitsuyoshi; Kawamori, Dan; Matsuoka, Taka-aki; Yamasaki, Yoshimitsu; Shimomura, Iichiro
• Is Part Of: Diabetes research and clinical practice. Volume 108:Issue 3(2015)
• Page Start: e35
• Page End: e37
• Publication Date: 2015-06
• Subjects: Retinopathy -- SNP -- MCP-1; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2015.04.006
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: MCP-1 plays an important role in the pathogenesis of diabetic retinopathy (DR). A-2518G polymorphism is reported to be associated with the production of MCP-1. We longitudinally examined the association between this polymorphism and onset of DR. The new onset of DR increased with the increase of the number of G alleles. Abstract: We longitudinally evaluated the association between monocyte chemoattractant protein-1 (MCP-1) A-2518G polymorphism and new onset of diabetic retinopathy in 758 type 2 diabetic patients. The new onset of retinopathy increased with the increase of the number of G alleles, even after adjustment for age, HbA1c levels, and duration of diabetes.