A Hyalinized Trichilemmoma of the Eyelid in a Teenager. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Jakobiec, Frederick A.; Stagner, Anna M.; Sassoon, Jodi; Goldstein, Scott; Mihm, Martin C.
• Is Part Of: Ophthalmic plastic and reconstructive surgery. Volume 32:Issue 1(2016:Jan./Feb.)
• Publication Date: 2016-01
• Subjects: Eye -- Surgery -- Periodicals; Ophthalmic plastic surgery -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Ophthalmologic Surgical Procedures -- Periodicals; Ophthalmology -- Periodicals; Surgery -- Periodicals; 617.70592
• DOI: 10.1097/IOP.0000000000000389
• Languages: English
• ISSNs: 0740-9303

Abstract

Abstract : A 16-year-old African American male, the youngest patient to date, presented with a well-circumscribed upper eyelid lesion. On excision, the dermal nodule was contiguous with the epidermis, displayed trichohyalin-like bodies in an expanded outer root sheath, and was composed chiefly of small cellular clusters separated by a prominent network of periodic acid Schiff -positive hyaline bands of basement membrane material. The tumor cells were positive for high molecular weight cytokeratins (CK) 5/6, CK14, and CK34βE12 and were negative for CK7, carcinoembryonic antigen and epithelial membrane antigen. Negative S100, glial fibrillary acidic protein, and smooth muscle actin immunoreactions ruled out a myoepithelial lesion. The Ki-67 proliferation index was <10%. The diagnosis was a hyalinized trichilemmoma, contrasting with the more common lobular type. As an isolated lesion, trichilemmoma does not portend Cowden syndrome.