Acute myocardial infarction complicating ischemic stroke: is there room for cangrelor?. (2nd January 2020)

• Record Type: Journal Article
• Authors: Morici, Nuccia; Nava, Stefano; Sacco, Alice; Viola, Giovanna; Oreglia, Jacopo; Meani, Paolo; Oliva, Fabrizio; Ranucci, Marco; Leonardi, Sergio; Rossini, Roberta
• Is Part Of: Platelets. Volume 31:Number 1(2020)
• Page Start: 120
• Page End: 123
• Publication Date: 2020-01-02
• Subjects: myocardial infarction -- stroke -- cangrelor; Blood platelets -- Periodicals; Blood Platelets -- Periodicals; 615.39
• DOI: 10.1080/09537104.2019.1609663
• Languages: English
• ISSNs: 0953-7104

Abstract

Abstract: Acute myocardial infarction (AMI) complicating ischemic stroke is a well known and undertreated event. A conservative management is not infrequent in these settings, due to the fear of hemorrhagic complications related to antithrombotic therapy. Notably, an invasive approach with a primary percutaneous coronary intervention (PCI) has been shown to be associated with a lower in-hospital mortality in patients with concomitant ischemic stroke and AMI. The optimal antiplatelet regimen in these cases has been not clearly defined, yet. We report two cases of patients with AMI complicating ischemic stroke, successfully treated with cangrelor infusion, which was started during PCI and maintained up to 48 h at bridge therapy dosage (0.75 mcg/kg/min). Both patients underwent successful PCI in the acute phase, and neither ischemic nor hemorrhagic complications occurred during in-hospital stay.