NIMG-51. THE IMPACT OF FUNCTIONAL MAGNETIC RESONANCE IMAGING ON CLINICAL OUTCOMES IN A PROPENSITY-MATCHED LOW GRADE GLIOMA COHORT. (5th November 2018)

• Record Type: Journal Article
• Authors: Megyesi, Joseph; Lau, Jonathan; Kosteniuk, Suzanne
• Is Part Of: Neuro-oncology. Volume 20(2018)Supplement 6
• Page Start: vi187
• Page End: vi187
• Publication Date: 2018-11-05
• Subjects: Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noy148.777
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: BACKGROUND: This study aims to evaluate the impact of preoperative functional magnetic resonance imaging (fMRI) on clinical outcomes in low grade glioma (LGG) patients. METHODS: In a retrospective propensity-matched cohort study, we compared LGG patients based on whether they underwent fMRI as part of preoperative assessment. Twelve LGG patients who underwent preoperative fMRI were selected, and a contemporaneous group of twelve control LGG patients who did not undergo fMRI were matched to the fMRI group based on age, sex and 1p/19q status. RESULTS: Functional MRI group subjects tended to have more aggressive surgeries (67% resection, 33% biopsy) than the control group (33% resection, 67% biopsy). There were no significant differences in outcomes between the groups. Time between clinical assessment and surgery tended to be longer in the fMRI group (6.3 +/- 4.2 weeks) than in the control group (2.7 +/- 2.2 weeks). Extent of resection was similar between the cohorts. Functional MRI groups subjects had lower preoperative functional status, and tended to have a greater postoperative functional status improvement than control group subjects. Mean survival was not significantly different (fMRI group five year survival 88.9%, control group five year survival 61.1%). CONCLUSIONS: We evaluated the impact of preoperative fMRI in patients with LGG in this propensity-matched cohort study. This study has not demonstrated any significant difference in outcomes between the fMRI and control groups, although there were non-significant trends for patients who underwent fMRI to undergo more aggressive surgical interventions, and have greater postoperative functional status improvement.