OS6.5 Randomized phase III trial comparing GAMMA KNIFE (GK) and LINAC based (EDGE) radiosurgery for brain metastases from solid tumors: results from the GADGET trial. (19th September 2018)

• Record Type: Journal Article
• Authors: Clerici, E; Navarria, P; Franzese, C; Carta, G A; Mancosu, P; Reggiori, G; Picozzi, P; Attuati, L; Tomatis, S; Scorsetti, M
• Is Part Of: Neuro-oncology. Volume 20(2018)Supplement 3
• Page Start: iii227
• Page End: iii227
• Publication Date: 2018-09-19
• Subjects: Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noy139.042
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: Background: Brain metastases (BMs) from solid tumors represent a topic of increasing interest for the higher incidence. Stereotactic radiosurgery is the main effective local therapeutic approach used. Different modalities have been employed, but to date no randomized comparative trials are available. We draw a phase III trial comparing Gammaknife (GK) and Linac based (Edge) radiosurgery with the aim to evaluate the incidence of symptomatic radionecrosis, local control and overall survival rates. Material and Methods: Patients 18–85 years old, with KPS ≥70, primary solid tumor, expected survival ≥ 3 months, and harboring up to 4 BMs with max tumor diameter ≤30 mm were included. Randomization was stratified according to age, presence of extracranial metastases, and the number of BMs. For Arm A (GK) a single dose of 20–24 Gy at 50% isodose was prescribed. For Arm B a single dose of 24 Gy was prescribed to PTV for all metastases. Outcome evaluation was performed every 3 months with MRI and clinical examination. Radionecrosis was assessed mismatching T1/T2 MRI images, perfusion MRI, and in doubt cases using Methionine-CT/PET. Local response was appraised according to the Response Assessment in Neuro-Oncology (RANO) Working Group criteria. Results: From October 2014 to January 2018, 168 patients for 292 BMs treated were included, 80 in Arm A (GK) and 88 in Arm B (Edge), for 152 BMs in arm A and 140 in Arm B, respectively. Symptomatic radionecrosis occurred in 23 (7.8%) cases, 11 in Arm A and 12 in Arm B; grade II in 8 cases of GK arm at a median time of 6.5 months and in 12 cases of Edge arm at a median time of 9.4 months; grade III RN was recorded in 3 cases, only in GK arm, at a median time of 3 months. The 12, and 18 months LC rates were 97.5% and 94.5% for the whole cohort; 98.8% and 90.9% for arm A; 96.2% and 96.2% for Arm B, comparable for the two groups (p value=0.96). The median, 12, and 18 months OS rates were 17.8 months, 74.1%, and 48.9%, comparable in both arms (p value=0.36). On univariate and multivariate analysis the volume of BMs was the only factor impacting on radionecrosis occurrence (p value=0.005; p value=0.03). Conclusion: Gamma-knife and LINAC based radiosurgery for BMs from solid tumors were comparable in terms of LC rates. The occurrence of G3 radionecrosis was greater and earlier in the GK arm respect to Edge arm.