RONC-16. RISK OF PREMATURE RADIONECROSIS IN PAEDIATRIC PATIENTS WITH HIGH RISK MEDULLOBLASTOMA TREATED WITH PROTONS ON THE CRANIUM SPINAL AXIS. Issue 2 (22nd June 2018)

• Record Type: Journal Article
• Authors: Colafati, Giovanna Stefania; Carducci, Chiara; Rombi, Barbara; Lorentini, Stefano; Carai, Andrea; Voicu, I Paul; Cacchione, Antonella; Mastronuzzi, Angela; Amichetti, Maurizio; Vennarini, Sabina
• Is Part Of: Neuro-oncology. Volume 20:Issue 2(2018)supplement 2
• Page Start: i177
• Page End: i178
• Publication Date: 2018-06-22
• Subjects: Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noy059.678
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: INTRODUCTION: Proton therapy (PT) is a radiation therapy in increasing use for paediatric cerebral tumours, as in medulloblastoma. Although publications to date are relatively limited, they however include cases of potential development of radionecrosis. The aim of this study has been to compare our experience with data found in literature relating to the insurgence of premature radionecrosis, evaluating incidence, timing, appearance of clinical symptoms, risk factors and radiological characteristics. MATERIALS AND METHODS: We have retrospectively analysed 10 children with high risk medulloblastoma using protons on the cranio-spinal axis with a dose equal to 36 Gy RBE and with a successive higher dose in the posterior cranial fossa of 18 Gy RBE, at the PT Centre in Trento. All patients underwent PT, post-surgery on the primary tumour and intensive myeloablative chemotherapy: both are two potential risk factors in the appearance of premature radionecrosis. All the patients also underwent MRI on the brain and bone marrow, before and after proton therapy treatment, at an interval of 1 month at the end of PT and then every 3 months. RESULTS: In our clinical records in a median follow up of 4.9 months we did not encounter cases of radionecrosis according to the definition criteria as discussed or published in the consulted publications. CONCLUSIONS: The paediatric patients with high risk medulloblastoma undergoing treatment with proton therapy, the subjects of our study, presented a lower risk to premature radionecrosis in respect to the data present in current publications.