QOL-48. SEIZURE IN PEDIATRIC PATIENTS WITH BRAIN TUMORS. Issue 2 (22nd June 2018)

• Record Type: Journal Article
• Authors: Robert-Boire, Viviane; Desnous, Béatrice; Weil, Alexander; Perreault, Sébastien
• Is Part Of: Neuro-oncology. Volume 20:Issue 2(2018)supplement 2
• Page Start: i167
• Page End: i167
• Publication Date: 2018-06-22
• Subjects: Brain Neoplasms -- Periodicals; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481
• DOI: 10.1093/neuonc/noy059.630
• Languages: English
• ISSNs: 1522-8517

Abstract

Abstract: BACKGROUND: Seizures are one of the most common symptoms of pediatric brain tumors. The purpose of this study was to determine seizures frequency and associated risk in pediatric patients with brain tumors. METHODS: A retrospective study was conducted in a single center over a period of 13 years. Data including demographic, tumor location, pathology, extend of resection, seizure characteristics were collected. A logistic regression model was built to determine which predictors are associated with the occurrence of seizures. RESULTS: Among the 329 children with primary brain tumors, 62 (18.8 %) experienced seizures. Children with cortical tumors were higher at risk to present seizures than patients with infratentorial tumors (OR=96.2; 95% CI=28.8-319.2; p<0, 0001). All patients with dysembryoplastic neuroepithelial tumor (DNET, 7/7) and 80% of glioneuronal tumors (8/10) experienced seizures. Twenty-nine patients had focal seizures with impaired awareness (46.8 %), while 25 had focal to bilateral tonic-clonic seizures (40.3 %), and 8 had focal aware seizures (12.9 %). Twenty-nine patients (46.8 %) were eventually seizure-free after antiepileptic drugs withdrawal, while ten patients (16.1 %) had refractory epilepsy. CONCLUSION: Our study is one of the largest cohorts of children with tumor-related seizures and brings new insight in term of seizures frequency, risk factors and evolution following treatment.