Hepatitis B Vaccination Induces Mucosal Antibody Responses in the Female Genital Tract, Indicating Potential Mechanisms of Protection Against Infection. Issue 5 (May 2019)

• Record Type: Journal Article
• Authors: Simpson, Samuel J.; Wiggins, Rebecca; Fox, James M.; Mthethwa, Jabu; Cai, Chun; Lacey, Charles J.N.
• Is Part Of: Sexually transmitted diseases. Volume 46:Issue 5(2019)
• Publication Date: 2019-05
• Subjects: Sexually transmitted diseases -- Periodicals; Sexual health -- Periodicals; 616.951005
• DOI: 10.1097/OLQ.0000000000000949
• Languages: English
• ISSNs: 0148-5717

Abstract

Abstract : Abstract: Vaccines against hepatitis B virus confer effective protection. Enzyme-linked immunosorbent assay was developed to test for specific antibodies in female genital tract secretions. Anti–hepatitis B IgG and IgA were detected in the cervicovaginal secretions of women after hepatitis B vaccination, indicating a potential genital tract role for neutralizing antibodies against sexually transmitted hepatitis B virus. Abstract : Specific hepatitis B antibodies were detected in the female genital tract of hepatitis B–vaccinated women and may be a component of protection against this virus.