Epithelial Claudin Proteins and Their Role in Gastrointestinal Diseases. Issue 5 (May 2019)

• Record Type: Journal Article
• Authors: Kim, David Y.; Furuta, Glenn T.; Nguyen, Nathalie; Inage, Eisuke; Masterson, Joanne C.
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 68:Issue 5(2019)
• Publication Date: 2019-05
• Subjects: celiac disease -- eosinophilic esophagitis -- inflammatory bowel disease -- liver disease -- tight junction; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000002301
• Languages: English
• ISSNs: 0277-2116

Abstract

Abstract : ABSTRACT: Our bodies are protected from the external environment by mucosal barriers that are lined by epithelial cells. The epithelium plays a critical role as a highly dynamic, selective semipermeable barrier that separates luminal contents and pathogens from the rest of the body and controlling the absorption of nutrients, fluid and solutes. A series of protein complexes including the adherens junction, desmosomes, and tight junctions function as the principal barrier in paracellular diffusion and regulators of intracellular solute, protein, and lipid transport. Tight junctions are composed of a series of proteins called occludins, junctional adhesion molecules, and claudins that reside primarily as the most apical intercellular junction. Here we will review one of these protein families, claudins, and their relevance to gastrointestinal and liver diseases.