Cardiorespiratory fitness is associated with inflammation and physical activity in HIV+ adults. (1st May 2019)

• Record Type: Journal Article
• Authors: Webel, Allison R.; Jenkins, Trevor; Vest, Marianne; Oliveira, Vitor H.F.; Longenecker, Chris T.; Liu, Jintao; Currie, Jackson; Sattar, Abdus; Josephson, Richard
• Is Part Of: AIDS. Volume 33:Number 6(2019)
• Publication Date: 2019-05-01
• Subjects: cardiorespiratory fitness -- cardiovascular diseases -- exercise -- heart -- HIV -- interleukin-6; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000002154
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : Objective: Our objective was to examine the effect of a lifestyle diet and exercise intervention on cardiorespiratory fitness (CRF) and to examine predictors of change in CRF. Design: People living with HIV (PLHIV) are at increased risk for cardiovascular disease. CRF is a better predictor of cardiovascular disease-related mortality than established risk factors yet very little is known about CRF in PLHIV. Methods: One-hundred and seven virally suppressed PLHIV were randomized to a group-based intervention to improve lifestyle behaviors or a control condition. All PLHIV maximal cardiorespiratory stress test to determine VO2 peak, VO2 at anaerobic threshold, and ventilatory efficiency/VCO2, at baseline and 6 months later. Participants wore an accelerometer to measure physical activity, completed waist–hip circumference measures, and had a fasting lipid profile, IL-6, and high sensitivity C-reactive protein analyzed. Generalized estimating equations were used to examine the effect of the intervention on CRF and predictors of change in CRF. Results: Participants were approximately 53 years old, 65% male ( n = 70), and 86% African-American ( n = 93). There was no effect of the intervention on markers of CRF over time ( P > 0.05). After controlling for age, sex, waist–hip-ratio, the inflammatory biomarker IL-6 was inversely associated with a decline in both VO2 peak ( P = 0.03) and VO2 at anaerobic threshold ( P = 0.03). In addition, participants who walked an additional 10 000 steps per day had a 2.69 ml/kg per min higher VO2 peak ( P = 0.02). Conclusion: Despite HIV viral suppression, PLHIV had remarkably poor CRF and inflammation was associated with a clinically adverse CRF profile. However, increased physical activity was associated with improved CRF.