More Than 12 % Polarization and 20 Minute Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water. (9th July 2018)

• Record Type: Journal Article
• Authors: McCormick, Jeffrey; Korchak, Sergey; Mamone, Salvatore; Ertas, Yavuz N.; Liu, Zhiyu; Verlinsky, Luke; Wagner, Shawn; Glöggler, Stefan; Bouchard, Louis‐S.
• Is Part Of: Angewandte Chemie. Volume 130:Number 33(2018)
• Page Start: 10852
• Page End: 10856
• Publication Date: 2018-07-09
• Subjects: Heterogene Katalyse -- Hyperpolarisation -- Parawasserstoff-induzierte Polarisation -- Polarisationstransfer -- Rhodium-Nanopartikel; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201804185
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Hyperpolarization techniques are key to extending the capabilities of MRI for the investigation of structural, functional and metabolic processes in vivo. Recent heterogeneous catalyst development has produced high polarization in water using parahydrogen with biologically relevant contrast agents. A heterogeneous ligand‐stabilized Rh catalyst is introduced that is capable of achieving 15 N polarization of 12.2±2.7 % by hydrogenation of neurine into a choline derivative. This is the highest 15 N polarization of any parahydrogen method in water to date. Notably, this was performed using a deuterated quaternary amine with an exceptionally long spin‐lattice relaxation time ( T 1 ) of 21.0±0.4 min. These results open the door to the possibility of 15 N in vivo imaging using nontoxic similar model systems because of the biocompatibility of the production media and the stability of the heterogeneous catalyst using parahydrogen‐induced polarization (PHIP) as the hyperpolarization method.