Dissipative Synthetic DNA‐Based Receptors for the Transient Loading and Release of Molecular Cargo. (2nd May 2018)

• Record Type: Journal Article
• Authors: Del Grosso, Erica; Amodio, Alessia; Ragazzon, Giulio; Prins, Leonard J.; Ricci, Francesco
• Is Part Of: Angewandte Chemie. Volume 130:Number 33(2018)
• Page Start: 10649
• Page End: 10653
• Publication Date: 2018-05-02
• Subjects: Dissipative Selbstorganisation -- DNA-Baueinheiten -- DNA-Nanotechnologie -- Supramolekulare Chemie -- Zeitliche Kontrolle; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201801318
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Supramolecular chemistry is moving into a direction in which the composition of a chemical equilibrium is no longer determined by thermodynamics but by the efficiency with which kinetic states can be populated by energy consuming processes. Herein, we show that DNA is ideally suited for programming chemically fueled dissipative self‐assembly processes. Advantages of the DNA‐based systems presented in this study include a perfect control over the activation site for the chemical fuel in terms of selectivity and affinity, highly selective fuel consumption that occurs exclusively in the activated complex, and a high tolerance for the presence of waste products. Finally, it is shown that chemical fuels can be used to selectively activate different functions in a system of higher complexity embedded with multiple response pathways.