Ring‐Opening Copolymerization of Maleic Anhydride with Functional Epoxides: Poly(propylene fumarate) Analogues Capable of Post‐Polymerization Modification. Issue 39 (27th August 2018)

• Record Type: Journal Article
• Authors: Chen, Yusheng; Wilson, James A.; Petersen, Shannon R.; Luong, Derek; Sallam, Sahar; Mao, Jialin; Wesdemiotis, Chrys; Becker, Matthew L.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 39(2018)
• Page Start: 12759
• Page End: 12764
• Publication Date: 2018-08-27
• Subjects: copolymerization -- polyesters -- polymers -- structure elucidation -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201807419
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Three functional epoxides were copolymerized with maleic anhydride to yield degradable poly(propylene fumarate) analogues. The polymers were modified post‐polymerization and post‐printing with either click‐type addition reactions or UV deprotection to either attach bioactive species or increase the hydrophilicity. Successful dye attachment, induced wettability, and improved cell spreading show the viability of these analogues in biomaterials applications. Abstract : Posthaste : Poly(propylene fumarate) was functionalized with chlorine, alkyne, and nitrophenyl groups by ring‐opening copolymerization of modified epoxides and maleic anhydride. These polymers can be modified by post‐polymerization and post‐printing.