Supramolecular Assemblies with Near‐Infrared Emission Mediated in Two Stages by Cucurbituril and Amphiphilic Calixarene for Lysosome‐Targeted Cell Imaging. (23rd August 2018)

• Record Type: Journal Article
• Authors: Chen, Xu‐Man; Chen, Yong; Yu, Qilin; Gu, Bo‐Han; Liu, Yu
• Is Part Of: Angewandte Chemie. Volume 130:Number 38(2018)
• Page Start: 12699
• Page End: 12703
• Publication Date: 2018-08-23
• Subjects: Calixarene -- Cucurbituril -- Nah-IR-aktive Aggregate -- Supramolekulare Chemie -- Zellbildgebung; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201807373
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: A two‐stage mediated near‐infrared (NIR) emissive supramolecular assembly for lysosome‐targeted cell imaging is presented. 4, 4′‐Anthracene‐9, 10‐diylbis(ethene‐2, 1‐diyl))bis(1‐ethylpyridin‐1‐ium) bromide (ENDT) was synthesized as an organic dye with weak fluorescence emission at 625 nm. When ENDT complexes with cucurbit[8]uril (CB[8]), this binary supramolecular complex assembles into nanorods with a near‐infrared fluorescence emission (655 nm) and fluorescence enhancement as the first stage. Such supramolecular complexes interact with lower‐rim dodecyl‐modified sulfonatocalix[4]arene (SC4AD) to form nanoparticles for further fluorescence enhancement as the second stage. Furthermore, based on a co‐staining experiment with LysoTracker Blue, such nanoparticles can be applied in NIR lysosome‐targeted cell imaging.