A Ligand‐Enabled Palladium‐Catalyzed Highly para‐Selective Difluoromethylation of Aromatic Ketones. (30th October 2018)
- Record Type:
- Journal Article
- Title:
- A Ligand‐Enabled Palladium‐Catalyzed Highly para‐Selective Difluoromethylation of Aromatic Ketones. (30th October 2018)
- Main Title:
- A Ligand‐Enabled Palladium‐Catalyzed Highly para‐Selective Difluoromethylation of Aromatic Ketones
- Authors:
- Tu, Guangliang
Yuan, Chunchen
Li, Yuting
Zhang, Jingyu
Zhao, Yingsheng - Abstract:
- Abstract: A practical and highly para ‐selective C−H difluoromethylation of aromatic ketones has been developed by employing tetrakis(triphenylphosphine)palladium(0) as the catalyst and triphenylphosphine as the ligand. In addition to general aromatic ketones, this transformation was compatible with bioactive compounds and well‐known drugs, such as oxybenzone, ketoprofen, zaltoprofen, and propafenone. Moreover, a mechanistic study revealed that a palladium intermediate coordinated by a carbonyl group promotes highly para ‐selective difluoromethylation.
- Is Part Of:
- Angewandte Chemie. Volume 130:Number 47(2018)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 130:Number 47(2018)
- Issue Display:
- Volume 130, Issue 47 (2018)
- Year:
- 2018
- Volume:
- 130
- Issue:
- 47
- Issue Sort Value:
- 2018-0130-0047-0000
- Page Start:
- 15823
- Page End:
- 15827
- Publication Date:
- 2018-10-30
- Subjects:
- Biologisch aktive Verbindungen -- Difluormethylierung -- Ligand -- Palladium -- Regioselektivität
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201809788 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 12313.xml