Solid‐Phase Conversion of Four Stereoisomers into a Single Enantiomer. (19th October 2018)

• Record Type: Journal Article
• Authors: Engwerda, Anthonius H. J.; Mertens, Johannes C. J.; Tinnemans, Paul; Meekes, Hugo; Rutjes, Floris P. J. T.; Vlieg, Elias
• Is Part Of: Angewandte Chemie. Volume 130:Number 47(2018)
• Page Start: 15667
• Page End: 15670
• Publication Date: 2018-10-19
• Subjects: Chiralität -- Deracemisierung -- Diastereomere -- Racemisierung -- Viedma-Reifung; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201808913
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Viedma ripening is an emerging method for the solid‐phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor‐made chiral additives, the conversion time can be reduced by a factor of 100.