Photobiocatalysis: Activating Redox Enzymes by Direct or Indirect Transfer of Photoinduced Electrons. Issue 27 (14th May 2018)

• Record Type: Journal Article
• Authors: Lee, Sahng Ha; Choi, Da Som; Kuk, Su Keun; Park, Chan Beum
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 27(2018)
• Page Start: 7958
• Page End: 7985
• Publication Date: 2018-05-14
• Subjects: artificial photosynthesis -- electron transfer -- photocatalysis -- photosensitizers -- redox biocatalysis; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201710070
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Biocatalytic transformation has received increasing attention in the green synthesis of chemicals because of the diversity of enzymes, their high catalytic activities and specificities, and mild reaction conditions. The idea of solar energy utilization in chemical synthesis through the combination of photocatalysis and biocatalysis provides an opportunity to make the "green" process greener. Oxidoreductases catalyze redox transformation of substrates by exchanging electrons at the enzyme′s active site, often with the aid of electron mediator(s) as a counterpart. Recent progress indicates that photoinduced electron transfer using organic (or inorganic) photosensitizers can activate a wide spectrum of redox enzymes to catalyze fuel‐forming reactions (e.g., H2 evolution, CO2 reduction) and synthetically useful reductions (e.g., asymmetric reduction, oxygenation, hydroxylation, epoxidation, Baeyer–Villiger oxidation). This Review provides an overview of recent advances in light‐driven activation of redox enzymes through direct or indirect transfer of photoinduced electrons. Abstract : Make the "green" process greener : This Review provides an overview of recent advances in the light‐driven activation of redox enzymes through direct or indirect transfer of photoinduced electrons. The construction of photocatalytic assemblies to activate different redox enzymes are outlined. The current challenges and strategies to advance photobiocatalytic transformations as a synthetic tool to meet an ever‐increasing demand for sustainable chemistry are presented.