The utility of a point‐of‐care sural nerve conduction device for detection of diabetic polyneuropathy: A cross‐sectional study. Issue 2 (24th December 2018)

• Record Type: Journal Article
• Authors: Kural, Mustafa A.; Andersen, Signe T.; Andersen, Niels T.; Andersen, Henning; Charles, Morten; Finnerup, Nanna B.; Jensen, Troels S.; Tankisi, Hatice
• Is Part Of: Muscle & nerve. Volume 59:Issue 2(2019)
• Page Start: 187
• Page End: 193
• Publication Date: 2018-12-24
• Subjects: diabetic polyneuropathy -- POCD -- nerve conduction study -- point‐of‐care nerve conduction device -- sural nerve; Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.26361
• Languages: English
• ISSNs: 0148-639X

Abstract

ABSTRACT: Introduction : Rapid and accessible methods for diagnosing diabetic polyneuropathy (DPN) have been developed, but not validated, in large cohorts of people with diabetes. Methods : The performance of a point‐of‐care device (POCD) was studied in 168 patients with type 2 diabetes, estimating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) compared with conventional sural nerve conduction studies (NCS). Results : A POCD amplitude limit of 6 µV increased the sensitivity (96%) and NPV (98%), but decreased the specificity (71%) and PPV (54%) compared with the 4‐µV limit, which had values of 78%, 92%, 89%, and 71%, respectively. POCD on both legs showed better performance than on 1 leg. POCD amplitudes and conduction velocities correlated significantly with conventional sural NCS, but POCD values were underestimated compared with NCS. Discussion : The POCD may be used as a suitable screening tool for detection of DPN. Patients with abnormal and borderline results should undergo conventional NCS. Muscle Nerve 59 :187–193, 2019