Copper(I)‐Catalyzed Enantio‐ and Diastereodivergent Borylative Coupling of Styrenes and Imines. (30th May 2018)

• Record Type: Journal Article
• Authors: Itoh, Taisuke; Kanzaki, Yamato; Shimizu, Yohei; Kanai, Motomu
• Is Part Of: Angewandte Chemie. Volume 130:Number 27(2018)
• Page Start: 8397
• Page End: 8401
• Publication Date: 2018-05-30
• Subjects: Asymmetrische Katalyse -- Borylierungen -- Chirale Amine -- Difunktionalisierungen -- Stereodivergente Reaktionen; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201804117
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: We report copper(I)‐catalyzed enantio‐ and diastereodivergent borylative coupling of styrenes and imines to produce enantiomerically‐enriched α, β‐dibranched γ‐boryl amine derivatives. Each of the four possible stereoisomers of the products, derived from the two contiguous stereocenters, was selectively accessible by choosing a proper chiral ligand for the copper catalyst. This method, which combines catalyst‐controlled stereodivergency and constitutional divergency derived from the lynchpin motif (i.e., the C−B bond), offers a strategy for addressing the construction of molecular structural diversity concomitant with precise chirality control.