Enantioselective Construction of Tertiary Boronic Esters by Conjunctive Cross‐Coupling. Issue 39 (29th August 2018)

• Record Type: Journal Article
• Authors: Myhill, Jesse A.; Zhang, Liang; Lovinger, Gabriel J.; Morken, James P.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 39(2018)
• Page Start: 12799
• Page End: 12803
• Publication Date: 2018-08-29
• Subjects: asymmetric catalysis -- boron -- cross coupling -- quaternary centers; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201807775
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Catalytic enantioselective conjunctive cross‐coupling has been developed to construct tertiary alkylboronic esters. These reactions occur with good yield and enantioselectivity for a range of substrates. Mechanistic experiments reveal aspects of the catalytic cycle that allow hindered substrates to react without significant complicating side reactions. Abstract : Catalytic conjunctive cross‐coupling has been developed to construct enantiomerically enriched tertiary alkylboronic esters. These reactions occur with good yield and enantioselectivity for a range of substrates. Mechanistic experiments reveal aspects of the catalytic cycle that allow hindered substrates to react without significant complicating side reactions.