Synthetic Protein Nanotubes: A Generic Self‐Assembly Process in Microcompartments and Synthetic Protein Nanotubes (Small 19/2018). Issue 19 (9th May 2018)

• Record Type: Journal Article
• Authors: Uddin, Ismail; Frank, Stefanie; Warren, Martin J.; Pickersgill, Richard W.
• Is Part Of: Small. Volume 14:Issue 19(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-05-09
• Subjects: bacterial microcompartment shell proteins -- protein nanotubes -- self‐assembly -- transmission electron microscopy; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201870087
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number 1704020, Richard W. Pickersgill and co‐workers uncover the orientation of shell proteins within synthetic protein nanotubes and bacterial microcompartments. The proteins form hexameric, or pseudo‐hexameric, disks which tessellate to form the nanostructures. The characteristics of the disks edges dictate that the concave surface of the disks faces exteriorly. An understanding of the orientation of these disks is crucial for biotechnological applications where nanobodies and enzymes are selectively targeted to the inside or outside of these structures.