Inside Back Cover: Metal‐ and Reagent‐Free Dehydrogenative Formal Benzyl–Aryl Cross‐Coupling by Anodic Activation in 1, 1, 1, 3, 3, 3‐Hexafluoropropan‐2‐ol (Angew. Chem. Int. Ed. 37/2018). Issue 37 (1st August 2018)

• Record Type: Journal Article
• Authors: Imada, Yasushi; Röckl, Johannes L.; Wiebe, Anton; Gieshoff, Tile; Schollmeyer, Dieter; Chiba, Kazuhiro; Franke, Robert; Waldvogel, Siegfried R.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 37(2018)
• Page Start: 12177
• Page End: 12177
• Publication Date: 2018-08-01
• Subjects: benzylic coupling -- electrochemistry -- green chemistry -- HFIP -- natural products; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201808283
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : The role of the bait in an electrochemical reaction of nucleophiles with activated substrates is played by 1, 1, 1, 3, 3, 3‐hexafluoropropan‐2‐ol (HFIP). In their Communication on page 12136 ff., S. R. Waldvogel et al. report the selective electrochemical benzylic activation of phenols and anisoles to generate HFIP ethers. HFIP is again liberated in the presence of acid, and the resulting benzylic cations react with a wide variety of nucleophiles, generating diarylmethanes in an environmentally friendly and safe process.