Enantioselective Functionalization of Enamides at the β‐Carbon Center with Indoles. (23rd October 2018) - Saputra, Mirza A.
Abstract: We report an enantioconvergent approach for the functionalization of enamides at the β‐carbon atom, which involves a chiral Brønsted acid induced tautomerization of 2‐amidoallyl into 1‐amidoallyl cations. These putative reactive intermediates were produced by ionization of racemic α‐hydroxy enamides with a chiral Brønsted acid and captured with substituted indoles in a highly regio‐ and enantioselective manner.