Statin-induced rhabdomyolysis: a complication of a commonly overlooked drug interaction. Issue 3 (14th March 2018)

• Record Type: Journal Article
• Authors: Ezad, Saad; Cheema, Hooria; Collins, Nicholas
• Is Part Of: Oxford medical case reports. Volume 2018:Issue 3(2018)
• Publication Date: 2018-03-14
• Subjects: Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1093/omcr/omx104
• Languages: English
• ISSNs: 2053-8855

Abstract

Abstract: Rhabdomyolysis is a well-documented side effect of statin therapy. This risk is increased with concurrent use of medications that inhibit cytochrome p450-3A4 (CYP3A4), such as macrolide antibiotics. We present the case of a 67-year-old patient who was commenced on clarithromycin on a background of simvastatin therapy, resulting in rhabdomyolysis. This case highlights the need for awareness of common drug interactions associated with statins. It also emphasizes the significance of commencing statins at a lower dose in new patients, and lastly, the importance of early recognition and management of rhabdomyolysis to prevent the development of complications.