Macrophages in radiation injury: a new therapeutic target. (3rd October 2018)

• Record Type: Journal Article
• Authors: Meziani, Lydia; Deutsch, Eric; Mondini, Michele
• Is Part Of: Oncoimmunology. Volume 7:Number 10(2018)
• Publication Date: 2018-10-03
• Subjects: Radiation injury -- macrophages -- immune system -- radiation toxicity -- lung fibrosis; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2018.1494488
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Radiotherapy can induce toxicity in healthy tissues such as radiation-induced fibrosis (RIF), and macrophages are proposed as new profibrogenic cells. In this Point-of-View, we summarize the role of the immune response in ionizing radiation injury, and we focus on macrophages as a new therapeutic target in RIF.