Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil. (15th October 2018)

• Record Type: Journal Article
• Authors: Brito, Dyego José de Araújo; dos Santos, Elisangela Milhomem; Dias, Raimunda Sheyla Carneiro; Calado, Isabela Leal; Silva, Gyl Eanes Barros; Lages, Joyce Santos; Monteiro Júnior, Francisco das Chagas; dos Santos, Alcione Miranda; Salgado Filho, Natalino
• Is Part Of: Renal failure. Volume 40:Number 1(2018)
• Page Start: 483
• Page End: 491
• Publication Date: 2018-10-15
• Subjects: Renal damage markers -- carotid atherosclerosis -- hypertension -- minority ethnic group -- Afro-descendants; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.1080/0886022X.2018.1496932
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Ethnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid intima-media thickness (CIMT) assessment. The presence of renal injury was assessed by: (1) The glomerular filtration rate (GFR) estimated by the formula CKD-EPI using creatinine and cystatin C and (2) Albuminuria (ACR ≥30 mg/g). The Poisson distribution model was set with robust variance to identify factors associated with carotid atherosclerosis. The statistical analysis was performed using the Stata 12.0 software, adopting a significance level of 5%. Most subjects were women (61.65%); the average age was 61.32 (±12.44) years. Subjects (12.62%) were identified with GFR <60 mL/min/1.73 m 2 and 22.8% with albuminuria. Patients (59.22%) presented with a high CIMT. In the adjusted regression model, age ≥60 years (PR: 1.232 [CI 95%:1.091–1.390], p value = .001), ACR ≥30 mg/g (PR: 1.176 [CI 95%: 1.007–1.373], p = .040), and GFR/CKD-EPI using cystatin C (PR: 1.250 [CI 95%: 1.004–1.557], p = .045) were independently associated with carotid atherosclerosis. The occurrence of atherosclerotic lesions was high in the studied group. Age, albuminuria, and GFR (estimated by the formula CKD-EPI using cystatin C) influenced the prevalence of carotid atherosclerosis.