Alkaloids and styryllactones from Goniothalamus cheliensis. (January 2019)

• Record Type: Journal Article
• Authors: Jaidee, Wuttichai; Andersen, Raymond J.; Patrick, Brian O.; Pyne, Stephen G.; Muanprasat, Chatchai; Borwornpinyo, Suparerk; Laphookhieo, Surat
• Is Part Of: Phytochemistry. Volume 157(2019)
• Page Start: 8
• Page End: 20
• Publication Date: 2019-01
• Subjects: Goniothalamus cheliensis -- Annonaceae -- Alkaloids -- Styryllactones; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2018.10.014
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Eight previously undescribed compounds, including four alkaloids and five styryllactones together with 36 known compounds were isolated from the twig and leaf extracts of Goniothalamus cheliensis . Their structures were elucidated by extensive analysis of their spectroscopic data. The absolute configuration of (−)-(4 S, 5 S, 6R, 7 S, 8 S )-goniochelienlactone and (−)-(4 S, 5 S, 6R, 7 S, 8 S )-7-acetylgoniochelienlactone were established from single crystal X-ray analysis using Cu Kα radiation. The absolute configurations of the other related compounds were identified by comparisons of their ECD spectra with those of related known compounds. Most of the isolated compounds were evaluated for their cytotoxicities against human colorectal cancer cells (HCT-116). Griffithazanone A was the most potent with an IC50 value of 2.39 μ M. Graphical abstract: Eight previously undescribed compounds were isolated and characterized from Goniothalamus cheliensis . Griffithazanone A showed potent cytotoxicities against human colorectal cancer cells (HCT-116). Image 1 Highlights: Forty-four compounds were isolated from Goniothalamus cheliensis. Four compounds were confirmed their structures by X-ray diffraction data. Griffithazanone A showed potent cytotoxicities against colorectal cancer cells.