Advanced dynamic statistical parametric mapping with MEG in localizing epileptogenicity of the bottom of sulcus dysplasia. Issue 6 (June 2018)

• Record Type: Journal Article
• Authors: Nakajima, Midori; Wong, Simeon; Widjaja, Elysa; Baba, Shiro; Okanishi, Tohru; Takada, Lynne; Sato, Yosuke; Iwata, Hiroki; Sogabe, Maya; Morooka, Hikaru; Whitney, Robyn; Ueda, Yuki; Ito, Tomoshiro; Yagyu, Kazuyori; Ochi, Ayako; Carter Snead, O.; Rutka, James T.; Drake, James M.; Doesburg, Sam; Takeuchi, Fumiya; Shiraishi, Hideaki; Otsubo, Hiroshi
• Is Part Of: Clinical neurophysiology. Volume 129:Issue 6(2018:Jun.)
• Page Start: 1182
• Page End: 1191
• Publication Date: 2018-06
• Subjects: Focal cortical dysplasia type II -- Dynamic statistical parametric mapping -- AdSPM spike source -- Phase-cancellation effect -- Source localization -- Epilepsy surgery; AdSPM advanced dynamic statistical parametric mapping -- BEM boundary element model -- BOSD bottom of sulcus dysplasia -- dSPM dynamic statistical parametric mapping -- FCDB focal cortical dysplasia at the bottom of sulcus -- MEG magnetoencephalography -- SMD single moving dipole -- SNR signal to noise ratio -- SPM statistical parametric mapping; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2018.03.007
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Advanced dynamic SPM (AdSPM) was applied to the bottom of sulcus dysplasia (BOSD). AdSPM localized epileptogenic BOSD more accurately than by the single moving dipole (SMD) method. AdSPM localizes BOSD both with and without an overlapping SMD-derived dipole cluster. Abstract: Objective: To investigate whether advanced dynamic statistical parametric mapping (AdSPM) using magnetoencephalography (MEG) can better localize focal cortical dysplasia at bottom of sulcus (FCDB). Methods: We analyzed 15 children with diagnosis of FCDB in surgical specimen and 3 T MRI by using MEG. Using AdSPM, we analyzed a ±50 ms epoch relative to each single moving dipole (SMD) and applied summation technique to estimate the source activity. The most active area in AdSPM was defined as the location of AdSPM spike source. We compared spatial congruence between MRI-visible FCDB and (1) dipole cluster in SMD method; and (2) AdSPM spike source. Results: AdSPM localized FCDB in 12 (80%) of 15 children whereas dipole cluster localized six (40%). AdSPM spike source was concordant within seizure onset zone in nine (82%) of 11 children with intracranial video EEG. Eleven children with resective surgery achieved seizure freedom with follow-up period of 1.9 ± 1.5 years. Ten (91%) of them had an AdSPM spike source in the resection area. Conclusion: AdSPM can noninvasively and neurophysiologically localize epileptogenic FCDB, whether it overlaps with the dipole cluster or not. Significance: This is the first study to localize epileptogenic FCDB using MEG.