Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves. (30th April 2018)

• Record Type: Journal Article
• Authors: Ariane, M.; Vigolo, D.; Brill, A.; Nash, F.G.B.; Barigou, M.; Alexiadis, A.
• Is Part Of: Computers & fluids. Volume 166(2018)
• Page Start: 57
• Page End: 63
• Publication Date: 2018-04-30
• Subjects: Discrete Multi-Physics -- Smoothed Particle Hydrodynamics -- Mass and Spring Model -- Biological venous valve -- Emboli -- Deep venous thrombosis; Fluid dynamics -- Data processing -- Periodicals; 532.050285
• DOI: 10.1016/j.compfluid.2018.01.037
• Languages: English
• ISSNs: 0045-7930

Abstract

Highlights: Development of a fully Lagrangian Discrete Multi-Physics model of a double venous valve system with flexible walls. The results highlight the effects of different sizes, shapes and elasticities of non-spherical emboli in the flow surrounding the valve. The key role of the length of the embolus on its own circulation in venous valve region. Abstract: Emboli, which are parts of blood clots, can be stuck in the vasculature of various organs (most frequently, lungs) and cause their malfunction or even death. In this work, using mathematical modelling, different types of emboli-like structures are studied in a double venous valve system. The model is implemented with a fully Lagrangian Discrete Multi-Physics technique and the flow is governed by flexible walls. The study shows the effect of different diameters and lengths of a free embolus in the flow surrounding the valve. The presence of an embolus strongly affects the dynamics of both the fluid and the leaflets in venous valves and the permanence of the embolus in the valve chamber is narrowly linked with its length.