A dual-sites fluorescent probe based on symmetric structure of naphthalimide derivative to detect H2S. (June 2019)

• Record Type: Journal Article
• Authors: Shi, Xurong; Yin, Caixia; Wen, Ying; Huo, Fangjun
• Is Part Of: Dyes and pigments. Volume 165(2019)
• Page Start: 38
• Page End: 43
• Publication Date: 2019-06
• Subjects: Hydrogen sulfide -- Dual-sites -- Symmetric structure -- Cell imaging; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2019.02.014
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Hydrogen sulfide (H2 S) is a powerful toxin which has a strong stimulating effect on the eye, respiratory system and central nervous system. Therefore, it is essential to detect H2 S in biological samples. Fluorescence imaging technology has the advantages of real-time and non-invasive, so it is very advantageous to detect H2 S in living cells. In this work, we designed and synthesized a fluorescent probe (named ND-N 3 ) based on naphthalimide derivative with symmetric structure and double recognition sites. The fluorescence intensity at 532 nm of ND-N 3 obviously increased with the increase of H2 S concentration. Apart from this, the probe showed excellent selectivity and rapid response time. More importantly, ND-N 3 can be used to detect endogenous/exogenous H2 S in living cells. Graphical abstract: Image 1 Highlights: A novel H2 S fluorescent probe (named ND-N 3 ) with dual-sites based on naphthalimide derivative. The application of the probe for selective detection H2 S in HepG-2 cells has been successfully demonstrated. The probe has a good linear relation and limit of detection is only 0.02 μM.