P338 Outcome of hospitalised patients with inflammatory bowel disease complicated by Clostridium difficile infection: Results from a tertiary referral centre. (16th January 2018) - Stoica, O
Abstract: Background: Previous studies reported conflicting results regarding outcome of hospitalised patients with inflammatory bowel disease (IBD) and concomitant Clostridium difficile infection (CDI). The aim of this study was to assess the outcome of IBD hospitalised patients with CDI compared with those without CDI. Methods: All IBD patients with and without CDI hospitalised in a single tertiary centre from January 1, 2011 through June 30, 2016 were identified and demographics, admission type (urgent vs. elective), length of hospital stay (LOS), surgery, and mortality were carefully recorded. Outcome of IBD patients with CDI was compared with that of patients without CDI. Results: There were 329 patients with IBD, median age 44 years (range: 19–81 years), most males (58.9%), predominantly with ulcerative colitis (69.3%). Out of them, 48 (14.5%) developed CDI: median age 46 years (range: 19–75 years), most males (66.6%), 35 (72.9%) patients with ulcerative colitis. IBD patients with CDI had a significant longer LOS compared with those without CDI (11.1 ± 5.8 vs. 8.3 ± 5.3 days, p = 0.001). There were no differences in colectomy or mortality rates between the two study groups. Conclusions: Despite contrasting results reported by several studies, IBD patients with concomitant CDI have short-term outcomes similar to IBD patients without CDI, except for a longer LOS. No significant differences in colectomy or mortality rates were found between IBD patients with and without CDI.