Concise synthesis of artemisinin from a farnesyl diphosphate analogue. Issue 7 (1st April 2018)

• Record Type: Journal Article
• Authors: Tang, Xiaoping; Demiray, Melodi; Wirth, Thomas; Allemann, Rudolf K.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 26:Issue 7(2018)
• Page Start: 1314
• Page End: 1319
• Publication Date: 2018-04-01
• Subjects: Malaria -- Artemisinin -- Amorphadiene synthase -- Dihydroartemisinic aldehyde -- Dihydroartemisinic acid -- Farnesyl diphosphate; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2017.03.068
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Artemisinin is one of the most potent anti-malaria drugs and many often-lengthy routes have been developed for its synthesis. Amorphadiene synthase, a key enzyme in the biosynthetic pathway of artemisinin, is able to convert an oxygenated farnesyl diphosphate analogue directly to dihydroartemisinic aldehyde, which can be converted to artemisinin in only four chemical steps, resulting in an efficient synthetic route to the anti-malaria drug.