The NDR/LATS protein kinases in immunology and cancer biology. (February 2018)

• Record Type: Journal Article
• Authors: Sharif, Ahmad A.D.; Hergovich, Alexander
• Is Part Of: Seminars in cancer biology. Volume 48(2018)
• Page Start: 104
• Page End: 114
• Publication Date: 2018-02
• Subjects: Serine/threonine protein kinases -- AGC kinases -- nuclear Dbf2-related kinase -- Large tumour suppressor kinase -- STK38 -- STK38L -- Immunology -- Cancer; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2017.04.010
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: The NDR (nuclear Dbf2-related)/LATS (large tumour suppressor) family of kinases represents a subclass of the AGC (protein kinase A (PKA)/PKG/PKC-like) group of serine/threonine protein kinases. Members of the NDR/LATS family are vital components of conserved pathways controlling essential cellular processes, such as proliferation (cell cycle progression) and cell death. In particular, the central involvement of NDR/LATS as YAP/TAZ kinases in the Hippo tissue growth control pathway has gained much interest. In this review, we summarise the roles of mammalian NDR1/2 (aka STK38/STK38L) and LATS1/2 in immunity and cancer biology. We also discuss the activation mechanisms of NDR/LATS involving Ste20-like kinases and the MOB1 signal transducer, followed by an overview of NDR/LATS knockout mouse models. We further review the mutation and expression status of NDR/LATS in human cancers and their possible predictive and/or prognostic value in cancer treatment.