Marked change in blood tacrolimus concentration levels due to grapefruit in a renal transplant patient. (23rd June 2019)

• Record Type: Journal Article
• Authors: Zhai, Xingyu; Chen, Chaoyang; Xu, Xin; Ma, Lingyue; Zhou, Shuang; Wang, Zhiqi; Ma, Lingyun; Zhao, Xia; Zhou, Ying; Cui, Yimin
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 44:Number 5(2019)
• Page Start: 819
• Page End: 822
• Publication Date: 2019-06-23
• Subjects: food‐drug interaction -- Grapefruit -- renal transplantation -- tacrolimus; Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.13002
• Languages: English
• ISSNs: 0269-4727

Abstract

Abstract: What is known and objective: Reveal the current status of grapefruit in the Chinese medical environment. Case description: An approximately 2‐fold increase in blood tacrolimus concentration was observed on day 9 in the hospital despite no change in dose. The only possible cause is that the patient had consumed grapefruit during hospitalization, which is often mistakenly considered to be a fruit belonging to the West and uncommon in the medical environment in China. What is new and conclusion: This is the first report of grapefruit‐induced blood tacrolimus concentration change. Chinese medical practitioners should re‐evaluate the impact of grapefruit and food‐drug interactions caused by it. Abstract : This is a case report of increased plasma concentration of tacrolimus in kidney transplant patients due to consumption of grapefruit, a fruit which Chinese people lack understanding of. Chinese medical practitioners should re‐evaluate the impact of grapefruit on Chinese medical environment and enhance patient education of grapefruit juice effect.