Microexons: novel regulators of the transcriptome. Issue 1 (1st January 2018)

• Record Type: Journal Article
• Authors: Curry-Hyde, Ashton; Chen, Bei Jun; Mills, James D.; Janitz, Michael
• Is Part Of: Journal of human transcriptome. Volume 2:Issue 1(2018)
• Page Start: 1
• Page End: 6
• Publication Date: 2018-01-01
• Subjects: Microexon -- genome -- transcriptome -- proteome -- RNA-Seq -- alternative splicing -- VAST-TOOLS; Life -- Origin -- Periodicals; RNA splicing -- Periodicals; Life -- Origin; RNA splicing; RNA Splicing; Transcriptome; Humans; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 572.8845
• DOI: 10.1080/23324015.2018.1491940
• Languages: English
• ISSNs: 2332-4015

Abstract

Abstract: Alternative splicing of RNA is a fundamental post-transcriptional regulatory process that leads to a vast diversity of proteins being translated from a relatively small number of genomic loci. Microexons, a set of very small protein-coding sequences of 1-17 amino acids, have only recently been recognised as an important part of pre-mRNA processing. Recent studies have revealed that microexons can play important roles in various cellular functions, protein-protein interactions and have also been associated with various neurological diseases. This review provides an update on research covering the functional impact of microexons on the biology of a cell and disease, and the mechanisms by which their splicing is regulated. Finally, the current bioinformatics methods for detecting microexons are discussed.