Identification and management of diabetic nephropathy. (October 2019)

• Record Type: Journal Article
• Authors: Muthuppalaniappan, Vasantha Muthu; McCafferty, Kieran; Sheaff, Michael; Yaqoob, Muhammad Magdi
• Is Part Of: Medicine. Volume 47:Number 10(2019)
• Page Start: 654
• Page End: 660
• Publication Date: 2019-10
• Subjects: Albuminuria -- chronic kidney disease -- diabetic nephropathy -- MRCP -- prevention -- risk factors; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Médecine factuelle -- Périodiques; Medicine; Periodicals; Electronic journals; Electronic journals; 610
• DOI: 10.1016/j.mpmed.2019.07.010
• Languages: English
• ISSNs: 1357-3039

Abstract

Abstract: Diabetic kidney disease is the leading cause of end-stage kidney disease in developed countries. It accounts for up to 40% of patients requiring renal replacement therapy. Optimum glycaemic and blood pressure control are currently the only strategies that have shown benefits in both prevention and attenuation of the progression of diabetic renal disease. However, recent discoveries of several underlying mechanisms have led to the discovery of novel promising therapeutic targets awaiting outcomes studies. In ongoing outcome trials, new antihyperglycaemic agents in particular have demonstrated very promising results independent of glucose control.